Effect of fangchinoline on root resorption during rat orthodontic tooth movement
Bao Xingfu, Hu Min, Zhang Yi, Machibya Ferdinand, Zhang Ying, Jiang Huan, Yu Dongsheng,
소속 상세정보
( Bao Xingfu ) - Jilin University School of Stomatology Department of Orthodontics
( Hu Min ) - Jilin University School of Stomatology Department of Orthodontics
( Zhang Yi ) - Jilin University School of Stomatology Department of Orthodontics
( Machibya Ferdinand ) - Jilin University School of Stomatology Department of Orthodontics
( Zhang Ying ) - Jilin University School of Stomatology Department of Orthodontics
( Jiang Huan ) - Jilin University School of Stomatology Department of Orthodontics
( Yu Dongsheng ) - Jilin University School of Stomatology Department of Orthodontics
KMID : 0361920120420030138
Abstract
Objective: To evaluate the short-term effect of fangchinoline, an antiinflammatory drug widely used in Asia, on root resorption that is associated with orthodontic tooth movement.
Methods: Twenty-four Wistar rats were randomly divided into 6 groups. Mesial forces of 0, 50, or 100 g were applied to the maxillary first molar of the rats in each group for 14 days by activating nickel-titanium closed-coil springs. One-half of the rats receiving each of these treatments also received injections of 200 μL fangchinoline every 2 days. Finally, movement of
the maxillary first molars was measured using digitized radiographs. The molars were extracted and the surfaces of the root resorption craters were recorded using a scanning electron microscope. The distance the molars moved and resorptionarea ratio was measured, and results were analyzed using 2-way ANOVA tests.
Results: There were no statistical differences in the distances the first molars moved under 50 or 100 g force, regardless of treatment with fangchinoline. However, the resorption area ratios were significantly smaller in those rats that were treated with both tension and fangchinoline than in those rats treated by tension alone.
Conclusions: Fangchinoline reduced the resorption area ratio in rats and is therefore an important means of alleviating root resorption.
키워드
SEM;Root resorption;Tooth movement
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